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KMID : 0361619760110010098
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Journal of the Korean Orthopaedic Association
1976 Volume.11 No. 1 p.98 ~ p.103
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The Diagnostic Value of the Nitroblue Tetrazolium Dye Reduction Test in Orthopaedic Field
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朴炳守/Park, Byoung-Soo
朴莊圭/趙德衍/金基容/趙明俊/Park, Jang-Kyu/Cho, Duck-Yum/Kim, Key-Yong/Cho, Myoung-Jun
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Abstract
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Nitroblue tetrazolium dye reduction test is now widely used for early detection of bacterial infection.
Practically nitroblue tet>2´azolium dye reduction test (N. B. T. test) gives certain clue to rule out any possibility of aseptic inflammation.
Authors performed N. B. T. test for 80 orthopaedic diseases and 40 controls, and the results were as followings:
1. Forty-one of EO~ubjects with bacterial infection had more than 10% formazan positive neutrophils, and 18 of 20 subjects without bacterial infection showed less than 10% formazan positive neutrophils.. The groups of the elevated N. B. T. responses were mainly the subjects who had osteomyelitis, soft tissue inflammation, pyogenic arthritis, and bone and joint tuberculosis. i
2. The mean proportion of N. B. T. positive neutrophils was 3.82.78 j in 40 controls, 4.7 4.23% in 20 nonifectious group, 12.710.3% in 12 chronic osteomyelitis, 12.510.7% in 15 treated bone and joint tuberculosis, 20.915.65% in 15 untreated bone and joint tuberculosis and 2010.70% in 11 pyogenic arthritis and 7 other soft inflammatory group.
3. Inoninfectious group, 7 of 8 subjects with elevated ESR and 3 of 4 subjects with elevated body temperature revealed N. B. T. responses less than 10%.
4. In 23 subjects with the elevated N. B. T. responses as well as leukecytosis, 22 subjects were the groups of bacterial infection and rest 1 was noninfectious in nature.
5. Therefore, the N. B. T. test is found to be useful for the purposes of the early diagnostic aid of the bacterial infection and differential diagnosis between bacterial infections and other diseases.
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